Qualitative and Quantitative Analysis of Chest CT Features of Anti-MDA5 Antibody Positive Dermatomyositis
10.3969/j.issn.1005-5185.2024.06.006
- VernacularTitle:血清抗黑色素瘤分化相关基因5阳性皮肌炎胸部CT特征定性及定量分析
- Author:
Lei WANG
1
;
Yanyan XU
;
Zhenguo HUANG
;
Yanhong REN
;
Xiaoming SHU
;
Min LIU
Author Information
1. 中日友好医院放射诊断科,北京 100029
- Keywords:
Anti-melanoma differentiation related gene 5 antibody;
Dermatomyosistis;
Interstitial lung disease;
Tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging
2024;32(6):559-563,571
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the CT imaging features of dermatomyosistis patients with anti-melanoma differentiation related genes 5(MDA-5),and to analyze the relationship between CT imaging indicators and short-term prognosis of patients.Materials and Methods Sixty-seven MDA-5-positive dermatomyosistis patients admitted to China-Japan Friendship Hospital from January 2017 to December 2018 were retrospectively included.Prognosis of included patients in one year were followed-up.Analysis of the relationship between chest CT imaging and short-term poor prognosis.Results Among 67 patients,nine patients died in one year.There was a statistically significant difference between the two groups(the death group and the survivor group)in the interstitial lung disease(ILD)imaging types(χ2=0.198,P=0.025)and pulmonary/aortic diameter ratios(U=103.0,P=0.004).CT imaging of dermatomyosistis-ILD with anti-MDA5 antibody positive patients showed organizing pneumonia.Mortality of diffuse alveolar damage type was significantly higher than that of other types.Logistic regression analysis showed that pulmonary/aortic diameter ratio(OR:4.208,P=0.002)was a strong independent risk factor for the death of patients with anti-MDA5 antibody.Conclusion Most patients with anti-MDA5 antibody positive dermatomyositis show ILD,with the main feature of organic pneumonia.Patients with poor prognosis within 1 year have different types of ILD,while the pulmonary/aortic diameter ratio is a strong independent risk factor for the death of dermatomyosistis-ILD with anti-MDA5 antibody positive patients.
