Advancements in the Application of PET-Based Radiomics in the Assessment of Alzheimer's Disease

VernacularTitle:基于PET的影像组学在阿尔茨海默病评估中的应用进展
Author: Cheng TANG ^{1
,

2} ; Weiwei RUAN ; Xiaoli LAN ; Xun SUN
Author Information

1. 华中科技大学同济医学院附属协和医院核医学科,湖北武汉 430022
2. 华中科技大学同济医学院第一临床学院,湖北武汉 430022
Keywords: Alzheimer's disease; Positron emission tomography; Biomarkers; Radiomics; Review
From: Chinese Journal of Medical Imaging 2024;32(5):504-509
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)is a common chronic neurodegenerative disorder.PET,a non-invasive molecular imaging technique,plays a significant role in diagnosing AD by revealing characteristic pathological changes.Meanwhile,radiomics technology can extract a vast amount of information that is difficult to recognize by the naked eye,and provides an objective and quantitative method for analyzing PET image features of AD patients.This article introduces the general steps of radiomics and common tools for PET image analysis applied in the assessment of AD.It also reviews the current research status of radiomics based on PET imaging in the diagnosis and prognosis prediction of AD,focusing on amyloid β,tau proteins and cerebral glucose metabolism.Furthermore,the article discusses future challenges in this field.