Correlation Between Molecular Typing and Imaging Findings of Simultaneous Bilateral Breast Cancer
10.3969/j.issn.1005-5185.2024.05.008
- VernacularTitle:同时性双侧乳腺癌分子分型与乳腺影像表现的相关性
- Author:
Yan LI
1
;
Qing LIN
;
Chunxiao CUI
;
Xiaohui SU
;
Tiantian BIAN
;
Qi ZHANG
;
Xia ZHOU
Author Information
1. 青岛大学附属医院乳腺影像科,山东青岛 266000
- Keywords:
Breast neoplasms;
Molecular typing;
Mammography;
Magnetic resonance imaging;
Pathology,surgical
- From:
Chinese Journal of Medical Imaging
2024;32(5):461-467
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To analyze the relationship between different molecular types and imaging manifestations of simultaneous bilateral breast cancer.Materials and Methods Eighty-one patients with simultaneous bilateral breast cancer confirmed by surgery and pathology in the Affiliated Hospital of Qingdao University from January 2016 to May 2022 were retrospectively analyzed,80 patients received mammography and 38 patients received MRI.Imaging features referred to the 5th edition of the breast imaging reporting and data system standards.Molecular typing was evaluated and classified according to the 2013 revised St.Gallen international expert consensus recommended the determination.The clinicopathological and imaging features of the index and contralateral breast cancer were compared,and the imaging features of different molecular types of the index and contralateral breast cancer were also compared.Results There were statistically significant differences in histological types and molecular typing between the index and contralateral cancers(x2=39.72,12.23,P＜0.05).Mammograph showed that the index cancer was mostly a mass(51.9％,40/77),while the contralateral cancer was mostly calcification(38.4％,28/73);the index cancer was mostly polymorphic calcification(68.8％,22/32),while the contralateral cancer was mostly amorphous calcification(45.2％,19/42)(x2=33.15,10.47,P＜0.05).There was a statistically significant difference in the MRI enhancement between the index cancer and the contralateral cancer(x2=6.79,P＜0.05).For contralateral cancer,mammograms showed statistically significant differences in the four molecular subtypes on tumor density,as well as MRI enhancement patterns,early enhancement degree,and time-signal intensity curve(x2=26.72,7.49,8.95,13.44,12.85,P＜0.05).There was a significant difference in the distribution of calcification among the four molecular subtypes on the X-ray of the first cancer(x2=20.15,P＜0.05).Conclusion The molecular typing and some imaging characteristics of simultaneous bilateral breast cancer are different,and some imaging characteristics can provide reference for predicting the molecular typing of simultaneous bilateral breast cancer.
