Application of Clinical and Ultrasound-Based Model in Secondary Hyperparathyroidism
10.3969/j.issn.1005-5185.2024.05.006
- VernacularTitle:临床-超声参数模型在继发性甲状旁腺功能亢进症中的应用
- Author:
Jinmei MA
1
;
Xinhui SHI
;
Yanfei KANG
;
Chunli CAO
;
Wen LIU
;
Jing CHENG
;
Jun LI
Author Information
1. 石河子大学第一附属医院超声医学科,新疆石河子 832008
- Keywords:
Clinical and ultrasound-based model;
Virtual touch tissue imaging quantification;
Secondary hyperparathyroidism;
Parathyroid hormone;
Ultrasonography
- From:
Chinese Journal of Medical Imaging
2024;32(5):447-453
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the application value of clinical-ultrasound parameter model in secondary hyperparathyroidism(SHPT).Materials and Methods A total of 86 patients(134 lesions)with renal insufficiency who underwent maintenance hemodialysis in the First Affiliated Hospital of Shihezi University from October 2020 to August 2022 were included and divided into group 1 according to the level of parathyroid hormone(iPTH)(iPTH＜300 pg/ml),group 2(iPTH 300-800 pg/ml)and group 3(iPTH≥800 pg/ml),all patients underwent gray-scale parathyroid ultrasound and acoustic palpation tissue quantitative imaging examinations.The characteristics of glandular gray-scale ultrasound and virtual touch tissue imaging quantification parameters between different groups,combined with relevant clinical indicators,established a clinical-ultrasound parameter model,used multiple linear regression to analyze the correlation between the model and iPTH,explored the independent risk factors of iPTH,and evaluated this model to evaluate SHPT the value of.Results There were significant differences in dialysis age,phosphorus,alkaline phosphatase,serum creatinine,corrected calcium and phosphorus product,lesion size,number,echo,shear wave velocity(SWV)max,SWVcen,and SWVmean among the three groups(F/x2/H=6.396-53.524,all P＜0.05).Dialysis age,phosphorus,alkaline phosphatase,and SWVratio were independent influencing factors of iPTH level(β=0.514,0.422,0.226,-0.368,all P＜0.005).The area under the curve,sensitivity,specificity and accuracy of the model for diagnosing SHPT and predicting surgical treatment with iPTH levels of 300 pg/ml and 800 pg/ml were 0.967,95.00％,100.00％,97.73％and 0.824,77.42％,71.43％and 90.00％,respectively.Conclusion Dialysis age,phosphorus,alkaline phosphatase and SWVratio are independent influencing factors of iPTH level,and the clinical-ultrasound parameter model is of great value in accurately assessing the severity of SHPT.
