Multiparametric quantitative MRI for diagnosis of thyroid-associated ophthalmopathy complicated with dysthyroid optic neuropathy
10.13929/j.issn.1003-3289.2024.11.008
- VernacularTitle:多参数定量MRI诊断甲状腺相关眼病合并甲状腺功能障碍性视神经病变
- Author:
Pai PENG
1
;
Xinyi GOU
;
Tianyuan LI
;
Xiuying ZHANG
;
Jin CHENG
Author Information
1. 北京大学人民医院放射科,北京 100871
- Keywords:
eye;
optic nerve;
thyroid gland;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2024;40(11):1667-1671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of multiparametric quantitative MRI for diagnosis of thyroid-associated ophthalmopathy(TAO)complicated with dysthyroid optic neuropathy(DON).Methods Fifty-five TAO patients with 109 affected eyes were retrospectively enrolled and divided into DON group(22 cases with 44 affected eyes)and non DON group(33 cases with 65 affected eyes)based on complicated with DON or not.Clinical data and multiparametric quantitative MRI indicators were compared between groups.The influencing factors of TAO complicated with DON were screened with logistic regression to establish a model,and the diagnostic efficacy of the model was observed.Results Significant differences of the course of disease,degree of eyeball protrusion,muscle index,as well as the number,thickness,T1 value,T2 value,fat fraction and orbital fat water fraction of thickened extraocular muscle were found between groups(all P＜0.05).T1 value and orbital fat water fraction of thickened extraocular muscle were both independent influencing factors of TAO complicated with DON,with the area under the curve(AUC)for diagnosing TAO complicated with DON of 0.859 and 0.868,respectively,and AUC of the combined diagnosis of the two was 0.922,significantly higher than orbital fat water fraction alone(P=0.034)but not significantly different with that of T1 value alone(P=0.851).Conclusion T1 value and orbital fat water fraction of thickened extraocular muscle based on multiparametric quantitative MRI were helpful for diagnosing TAO complicated with DON.
