Changes of brain networks function in patients with primary dysmenorrhea during menstruation
10.13929/j.issn.1003-3289.2024.11.007
- VernacularTitle:原发性痛经患者月经期脑网络功能改变
- Author:
Zhongxu ZHANG
1
;
Cong ZHANG
;
Yunsong ZHENG
;
Feng ZHOU
;
Yuan WANG
;
Zhiqun WANG
;
Xiaotong MA
Author Information
1. 陕西中医药大学附属医院医学影像科,陕西 咸阳 712000
- Keywords:
dysmenorrhea;
magnetic resonance imaging;
brain network;
prospective studies
- From:
Chinese Journal of Medical Imaging Technology
2024;40(11):1661-1666
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of brain networks function in patients with primary dysmenorrhea(PDM)during menstruation based on topological attributes of brain network.Methods Brain resting-state functional MRI of 57 PDM patients(PDM group)and 50 healthy women(health control[HC]group)were prospectively collected within the first or the second day of menstruation.Clinical scores were obtained and compared between groups.Results Visual analogue scale,cox menstrual symptom scale,self-rating anxiety scale and self-rating depression scale scores in PDM group were all higher than those in HC group(all P＜0.05).At the sparsity of 0.04-0.50,brain networks in both groups conformed to the small world attribute characteristics,and no significant difference of global attributes of brain network was found between groups(all P＞0.05).The node efficiency(Ne)and node degree(Dc)of bilateral posterior cingulate gyrus(PCG),as well as De and node betweenness(Bc)of left middle frontal gyrus(MFG)in PDM group were all higher than those in HC group,while Ne and De of left inferior temporal gyrus in PDM group were lower than those in HC group(all P＜0.01).Compared with HC group,the functional connections between left PCG and right calcarine fissure and surrounding cortex,right lingual gyrus and left MFG,as well as between right PCG and right dorsolateral superior frontal gyrus and left MFG,between right insula and left middle occipital gyrus enhanced in PDM group(all P＜0.001).Conclusion In PDM patients,local brain networks function such as default mode network,central executive network and salience network were over-activated during menstruation,yet the overall brain network still had good coordination and organization.
