A study on the safety and efficacy of bovine bone-derived bone graft material(OCS-B).
10.5051/jkape.2005.35.2.335
- Author:
Ho Nam PARK
1
;
Sang Hyuk HAN
;
Kyoung Hwa KIM
;
Sang Chul LEE
;
Yoon Jeong PARK
;
Sang Hoon LEE
;
Tae Il KIM
;
Yang Jo SEOL
;
Young KU
;
In Chul RHYU
;
Soo Boo HAN
;
Chong Pyoung CHUNG
Author Information
1. Department of Periodontology, College of Dentistry, Seoul National University , Korea. ccpperio@snu.ac.kr
- Publication Type:Original Article
- Keywords:
bovine bone;
bone regeneration;
calvarial defect
- MeSH:
Animals;
Bone Regeneration;
Durapatite;
Mice;
Orthopedics;
Rabbits;
Residence Characteristics;
Transplants*
- From:The Journal of the Korean Academy of Periodontology
2005;35(2):335-343
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Inorganic bovine bone mineral has been widely researched as bone substitution materials in orthopedic and oral and maxillofacial application. OCS-B(NIBEC, Korea) is newly-developed inorganic bovine bone mineral. The aim of this study is to evaluate the safety and efficacy of bovine bone-derived bone graft material(OCS-B). Micro-structure of newly-developed inorganic bovine bone mineral(OCS-B) was analyzed by scanning electron microscope(SEM). Round cranial defects with eight mm diameter were made and filled with OCS-B in rabbits. OCS-B was inserted into femoral quadrant muscle in mouse. In scanning electron microscope, OCS-B was equal to natural hydroxyapatite. Rabbits were sacrificed at 2 weeks and 4 weeks after surgery and mice were sacrificed at 1 week and 2 weeks after surgery. Decalcified specimens were prepared and observed by microscope. In calvarial defects, osteoid and new bone were formed in the neighborhood of OCS-B at 2 weeks after surgery. And at 4 weeks after surgery osteoid and new bone bridge formed flourishingly. No inflammatory cells were seen on the surface of OCS-B at 1 week and 2 weeks in mouse experimental group. It is concluded that newly-developed inorganic bovine bone mineral(OCS-B) is a flourishing bone-forming material and biocompatible material.
