3D amide proton transfer weighted imaging combined with diffusion weighted imaging for differentiating benign and malignant bone and soft tissue tumors
10.13929/j.issn.1003-3289.2024.10.024
- VernacularTitle:3D氨基质子转移加权成像联合弥散加权成像鉴别良、恶性骨与软组织肿瘤
- Author:
Ying LI
1
;
Jingliang CHENG
;
Cuiping REN
;
Yong ZHANG
;
Wenhua ZHANG
;
Liangjie LIN
Author Information
1. 郑州大学第一附属医院磁共振科,河南郑州 450052
- Keywords:
bone neoplasms;
soft tissue neoplasms;
magnetic resonance imaging;
amide proton transfer;
prospective studies
- From:
Chinese Journal of Medical Imaging Technology
2024;40(10):1572-1576
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of 3D amide proton transfer weighted imaging(APTWI),diffusion weighted imaging(DWI)and the combination for differentiating benign and malignant bone and soft tissue tumors.Methods Non-contrast MRI,APTWI and DWI of pelvis or lower extremity were prospectively acquired in 96 patients with bone and soft tissue tumors.MTRasym and ADC maps were obtained based on APTWI and DWI calculation with an offset of 3.5 ppm,respectively,and the maximum asymmetric magnetization transfer rate(MTRasym)(MTRasymmax),the mean MTRasym(MTRasymmean)and the minimum MTRasym(MTRasymmin),as well as the maximum apparent diffusion coefficient(ADC)(ADCmax),the mean ADC(ADCmean)and the minimum ADC(ADCmin)values were measured.The above parameters were compared between benign and malignant tumors.Then receiver operating characteristic curve was drawn,and the area under the curve(AUC)was calculated to evaluate the efficacy of APTWI,DWI and the combination.Results Among 96 patients,there were 41 benign and 55 malignant pelvic or lower limb bone and soft tissue tumors.In benign tumors,MTRasym(3.5 ppm)values,including MTRasymmax.MTRasymmean and MTRasymmin were significantly higher,whereas ADC values including ADCmax,ADCmeanand ADCmin were significantly lower than those in malignant tumors(all P＜0.05).AUC of MTRasymmax and ADCmin for differentiating benign and malignant bone and soft tissue tumors was 0.791 and 0.873,respectively,being not statistically different(P=0.122),but both lower than that of their combination(AUC=0.944,P＜0.001,P=0.041).Conclusion APTWI combined with DWI had high efficacy for differentiating benign and malignant bone and soft tissue tumors.
