O-RADS ultrasound 4 subclassification combined with CA125,HE4 and RMI 4 for predicting malignant risk of ovarian-adnexal masses
10.13929/j.issn.1003-3289.2024.10.019
- VernacularTitle:超声O-RADS 4亚分类联合CA125、HE4及RMI 4预测卵巢-附件肿块恶性风险
- Author:
Xin LIU
1
;
Anyan ZHOU
;
Rong HU
Author Information
1. 新疆医科大学第一附属医院妇产超声诊断科(新疆超声医学重点实验室),新疆乌鲁木齐 830054
- Keywords:
adnexal diseases;
pathology;
ultrasonography
- From:
Chinese Journal of Medical Imaging Technology
2024;40(10):1548-1551
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of ovarian-adnexal reporting and data system(O-RADS)ultrasound 4 subcategory combined with carbohydrate antigen 125(CA125),human epididymis protein 4(HE4)and the risk of malignancy index 4(RM1 4)for predicting malignant risk of ovarian-adnexal masses.Methods Data of 142 patients with O-RADS ultrasound 4 ovarian-adnexal masses were retrospectively analyzed.According to pathological results,the patients were divided into benign group(n=104)and non-benign groups(n=38,including borderline and malignant tumors).Tumors with O-RADS subcategory 4a,CA125≤35 U/ml,premenopausal HE4≤70 pg/ml or postmenopausal HE4≤140 pg/ml,or RMI 4 total score ≤450 were regarded as probably benign ones,otherwise as probably malignant ones.The above 4 parameters were included to establish a logistic regression combination model for predicting the risk of malignancy of ovarian-adnexal masses of O-RADS ultrasound 4.The receiver operating characteristic curves were drawn,and the area under the curves(AUC)were calculated to evaluate the efficacy for predicting malignancy risk of each parameter alone and the combination model.Results The ratio of masses with a maximum diameter＞10 cm in non-benign group was higher than that in benign group(P＜0.05),while no significant difference of age nor menopausal status was found between groups(both P＞0.05).The AUC of O-RADS ultrasound 4 subcategory,CA125 level,HE4 level and RMI 4 score alone for predicting the risk of malignancy of ovarian-adnexal masses was 0.891,0.751,0.701 and 0.800,respectively,while of the combination model was 0.955,higher than that of each parameter alone(all P＜0.05).Conclusion Subcategory assessment of O-RADS ultrasound 4 ovarian-adnexal masses combined with CA125 level,HE4 level and RMI 4 score was efficient for predicting the risk of malignancy.
