Amide proton transfer imaging and MR spectroscopy for assessing central nervous system damages in stable chronic obstructive pulmonary disease
10.13929/j.issn.1003-3289.2024.10.006
- VernacularTitle:酰胺质子转移成像及MR波谱技术评估稳定期慢性阻塞性肺疾病中枢神经系统损伤
- Author:
Junjing HE
1
;
Lige ZHOU
;
Jiemei SUN
;
Zhiwei SHEN
;
Gang ZHANG
;
Wei XING
Author Information
1. 河南中医药大学第一附属医院磁共振科,河南郑州 450003
- Keywords:
pulmonary disease,chronic obstructive;
central nervous system;
magnetic resonance imaging;
magnetic resonance spectroscopy;
respiratory function tests
- From:
Chinese Journal of Medical Imaging Technology
2024;40(10):1481-1486
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of amide proton transfer(APT)imaging for assessing central nervous system damages in stable chronic obstructive pulmonary disease(COPD)and the correlations with MR spectroscopy(MRS)and lung function parameters.Methods Thirty-nine stable COPD patients(COPD group)and 34 healthy subjects(control group)were prospectively enrolled.Images of plain head MR,3D-APT and thalami MRS were acquired,and parameters of lung function were obtained.The basic data,outcomes of voxel-based morphometry(VBM)analysis,APT values in multiple brain regions and thalami MRS metabolite parameters were compared between groups,and the correlations of thalamus APT values with thalamus MRS metabolites parameters and lung function parameters were explored.Results Lung function parameters in COPD group were lower than those in control group,while cerebrospinal fluid volume(CSFV)and total brain volume(TIV)in COPD group were lager than those in control group(all P＜0.05).Compared with those in control group,APT values of bilateral thalami,right temporal lobe and right occipital lobe in COPD group were higher,and the peak value of N-acetyl aspartate(NAA)of bilateral thalami and NAA/creatin of right thalamus in COPD group were lower(all P＜0.05).Within COPD group,APT values of bilateral thalami were positively correlated(r=0.641),while APT values of left thalamus showed negative correlation(r=-0.435)with NAA values left thalamus and negative correlation(r=-0.432)with the forced expiratory volume in the first one second after bronchodilator administration(FEV1)(all P＜0.05).Conclusion APT values of central nervous system elevated and NAA values decreased in COPD patients.There were negative correlations between left thalamus APT and NAA values,also between APT values of left thalamus and FEV1.
