Automated net water uptake based on CT perfusion for predicting neurological prognosis of acute ischemic stroke
10.13929/j.issn.1003-3289.2024.10.003
- VernacularTitle:基于CT灌注自动化定量净摄水率预测急性缺血性脑卒中神经功能预后
- Author:
Xiaoping TENG
1
;
Jiulou ZHANG
;
Yue WANG
;
Chi ZHANG
;
Shanshan LU
;
Haibin SHI
Author Information
1. 南京医科大学第一附属医院放射科,江苏南京 210029
- Keywords:
ischemic stroke;
brain edema;
tomography,X-ray computed;
prognosis;
net water uptake
- From:
Chinese Journal of Medical Imaging Technology
2024;40(10):1466-1470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of automated net water uptake(CTP-aNWU)based on CT perfusion(CTP)for predicting neurological prognosis of acute ischemic stroke(AIS).Methods A total of 145 AIS patients due to anterior circulation large vessel occlusion were retrospectively enrolled,and the clinical data at admission and follow-up were collected.Alberta stroke program early CT score net water uptake(ASPECTS-NWU)was analyzed,and CTP-aNWU of the infarct core was obtained based on CTP and non-contrast CT(NCCT).According to modified Rankin scale(mRS)score 90 days after the onset of infarction,the patients were divided into favorable prognosis group(mRS score≤2,n=54)and poor prognosis group(mRS score＞2,n=91).The clinical data and imaging data were compared between groups,and the independent predictors of neurological prognosis of AIS were evaluated,and the predictive efficacies were assessed.Results There were significant differences in age,admission NIHSS score and admission ASPECTS of patients,as well as in ASPECTS-NWU,CTP-aNWU,infarct core volume,hypoperfusion factor of the lesions between groups(all P＜0.05).The infarct core volume(OR=0.977[0.963 to 0.992],P=0.002)and CTP-aNWU(OR=0.876[0.793 to 0.969],P=0.010)were independent predictors of neurological prognosis of AIS.The area under the curve(AUC)of receiver operating characteristic curve of CTP-aNWU alone for predicting neurological prognosis of AIS patients 90 days after the onset was 0.634(95％CI[0.550,0.713]),which was 0.790(95％CI[0.714,0.853])of CTP-aNWU combined with infarct core volume,and the latter was better than the former(Z=3.500,P＜0.001).Conclusion CTP-aNWU was an independent predictor of neurological prognosis 90 days after the onset of AIS.Combining CTP-aNWU with infarct core volume could improve the predicting efficacy.
