Chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease:Correlations with blood eosinophil level
10.13929/j.issn.1003-3289.2024.08.016
- VernacularTitle:慢性阻塞性肺疾病急性加重期患者胸部CT定量参数与血嗜酸性粒细胞水平的相关性
- Author:
Lu YANG
1
;
Yadan SHENG
;
Kai YANG
;
Liyu HE
;
Huihui GU
;
Guoqing SUN
;
Weiting CHEN
;
Bingjie ZHU
;
Yanrong CHEN
;
Chenwang JIN
Author Information
1. 西安交通大学第一附属医院医学影像科,陕西西安 710061
- Keywords:
pulmonary disease,chronic obstructive;
eosinophils;
tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2024;40(8):1189-1193
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 162 AECOPD patients with elevated eosinophils were retrospectively analyzed.The patients were divided into low EOS group(n=105)and high EOS group(n=57)according to the absolute counting of blood EOS.The quantitative CT parameters,including the number of whole lung bronchi and the volume of blood vessels,low-attenuation area percentage(LAA％)of whole lung,of left/right lung and each lobe of lung,as well as the luminal diameter(LD),wall thickness(WT),wall area(WA)and WA percentage of total bronchial cross-section(WA％)of grade 3 to 8 bronchi were compared between groups.Spearman correlations were performed to analyze the correlations of quantitative CT parameters with blood EOS level.Results LAA％of the whole lung,of the left/right lung and each lobe of lung,as well as of the upper lobe of right lung LDgrade4,middle lobe of right lung WTgrade5,upper lobe of right lung WAgrade4,middle lobe of right lung WAgrade5 and lower lobe of left lung WAgrade3 in low EOS group were all higher than those in high EOS group(all P＜0.05).Except for the upper lobe of right lung LDgrade4,the above quantitative CT indexes being significant different between groups were all weakly and negatively correlated with blood EOS level(r=-0.335 to-0.164,all P＜0.05).Conclusion Chest CT quantitative parameters of AECOPD patients were correlated with blood EOS level,among which LAA％,a part of WT and WA were all weakly negatively correlated with blood EOS level.
