Multimodal ultrasound for dynamic evaluating therapeutic effect of neoadjuvant chemotherapy for breast cancer
10.13929/j.issn.1003-3289.2024.07.013
- VernacularTitle:多模态超声动态评估乳腺癌新辅助化疗疗效
- Author:
Minlu YUE
1
;
Guiyan JIANG
Author Information
1. 北京大学肿瘤医院内蒙古医院,内蒙古医科大学附属肿瘤医院超声科,内蒙古呼和浩特 010020
- Keywords:
breast neoplasms;
ultrasonography;
treatment outcome;
neoadjuvant chemotherapy
- From:
Chinese Journal of Medical Imaging Technology
2024;40(7):1020-1024
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of multimodal ultrasound for dynamic evaluating the therapeutic effect of neoadjuvant chemotherapy(NACT)for breast cancer.Methods Data of 50 patients with single breast cancer who underwent complete NACT were retrospectively analyzed.The patients were divided into major histological response(MHR)group(n=26)and non-major histological response(NMHR)group(n=24)according to postoperative pathology.The changes of ultrasonic indicators of lesions before NACT and during the early,middle and late periods of NACT were comparatively observed between groups,so as the reduction rates of quantitative indicators during NACT between groups and within groups.Results After NACT,the maximum diameter of lesions,as well as the changes of lesions'maximum(Emax)and the mean(Emean)value of Young's modulus were significant different(all P＜0.05),while no significant difference of lesions'reduction modes nor blood flow classifications was found between groups(both P＞0.05).At early,middle and late periods of NACT,progressive reduction rate(PRR)of the maximum diameter of lesions in MHR group showed a decreasing trend,while showed decreasing trend at the middle but increasing trend at the later period of NACT in NMHR group.The total reduction rate(TRR)and PRR of lesions with the maximum diameter ≥2 cm(n=3,9)at all period of NACT were higher than those with the maximum diameter ＜2 cm in both groups(n=23,15,all P＜0.05).At early,middle and late periods of NACT,PRR of Emax and Emean within both groups showed gradually increasing trends,while TRR and PRR at all periods of NACT with Emax decreased ≥30％ lesions(n=14,5)were all higher than those with Emax decreased ＜30％ lesions(n=12,19),TRR and PRR at all periods of NACT of Emean decreased ≥30％ lesions(n=18,7)were all higher than those with Emean decreased ＜30％ lesions within both groups(n=8,17,all P＜0.05).Conclusion Multimodal ultrasound could be used to dynamically evaluate the efficacy of NACT for breast cancer,hence guiding the formulation of individualized treatment planning.
