Dynamic functional connectivity of brain networks in end-stage renal disease patients
10.13929/j.issn.1003-3289.2024.07.009
- VernacularTitle:终末期肾病患者脑网络动态功能连接
- Author:
Yaqian QIAO
1
;
Yulong WANG
;
Peirui BAI
;
Chengjian WANG
;
Yande REN
;
Yuzhen BI
Author Information
1. 青岛大学附属医院放射科,山东青岛 266100
- Keywords:
kidney failure,chronic;
magnetic resonance imaging;
functional connectivity
- From:
Chinese Journal of Medical Imaging Technology
2024;40(7):997-1002
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the temporal properties of dynamic functional connectivity of brain networks and the variability of network topology in patients with end-stage renal disease(ESRD).Methods Data of 30 ESRD patients(ESRD group)and 33 healthy subjects(control group)were retrospectively analyzed.Based on cranial resting-state functional MRI(rs-fMRI),dynamic functional connectivity(dFC)and graph theory analysis were employed,and the abnormalities in network topology and dFC in ESRD patients were assessed through comparison of groups.Pearson correlation analysis was used to observe the correlation between abnormal dFC indicators and clinical variables.Results Compared with control group,temporal scores and the mean residence time in ESRD group were significantly higher under state Ⅱ but significantly lower under state Ⅲ(both P＜0.05).The abnormal functional connectivity in ESRD patients under states Ⅱ and Ⅲ distributed mainly within and between default mode network,sensorimotor network,subcortical nuclei,execution and attention network,visual network and cerebellum networks.Network density and bilateral superior temporal gyrus nodal degrees in ESRD group were all significantly lower than those in control group(all P＜0.05).No significant correlation was found between the abnormal parameters of functional connectivity and graph theory attributes in ESRD group and clinical indicators under states Ⅱ nor Ⅲ(all P＞0.05).Conclusion ESRD patients had abnormal temporal attributes and network topology of brain dynamic networks related to cognitive impairments.
