Synthetic MRI and diffusion tensor imaging for evaluating grade and isocitrate dehydrogenase-1 status of adult gliomas
10.13929/j.issn.1003-3289.2024.06.006
- VernacularTitle:合成MRI及弥散张量成像评估成人胶质瘤级别与异柠檬酸脱氢酶-1状态
- Author:
Rui XU
1
;
Kukun HANJIAERBIEKE
;
Wei ZHAO
;
Tuxunjiang PAHATI
;
Yunling WANG
Author Information
1. 新疆医科大学第一附属医院影像中心,新疆乌鲁木齐 830054
- Keywords:
glioma;
isocitrate dehydrogenase;
magnetic resonance imaging;
diffusion tensor imaging
- From:
Chinese Journal of Medical Imaging Technology
2024;40(6):820-824
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of synthetic MRI(SynMRI)and diffusion tensor imaging(DTI)for evaluating grade and isocitrate dehydrogenase-1(IDH-1)status of adult gliomas.Methods Totally 115 patients with adult glioma were retrospectively enrolled and divided into adult low-grade glioma(aLGG)group(n=44)and adult high-grade glioma(aHGG)group(n=71)according to WHO classification.There were 30 cases of IDH-1 mutant type,2 cases of wild type and 12 cases of undetermined gliomas in aLGG group,whereas 26 cases of IDH-1 mutant type,24 cases of wild type and 21 cases undetermined gliomas in aHGG group,respectively.SynMRI and DTI parameters,including T1 value,T2 value,proton density(PD),apparent diffusion coefficient(ADC)and fractional anisotropy(FA)were compared between groups,and the efficacy of each parameter for distinguishing aLGG and aHGG,as well as IDH-1 mutant type and wild type was analyzed.Results Significant differences of T1 value,T2 value,ADC and FA were found between groups,also between IDH-1 mutant type and wild type gliomas within aHGG group(all P＜0.05).The area under the curve(AUC)of the above parameters for distinguishing aLGG and aHGG was 0.731,0.686,0.930 and 0.710,respectively,while for distinguishing IDH-1 mutant type and wild type in aHGG group was 0.775,0.729,0.817 and 0.705,respectively,among which ADC had the highest AUC(all P＜0.05).Conclusion SynMRI and DTI parameters such as T1 value,T2 value,ADC and FA were helpful for distinguishing aLGG and aHGG,IDH-1 mutant type and wild type,among which ADC had the highest efficacy.
