18F-FDG PET/CT semi-quantitative parameters for predicting clinical stage Ⅰa—Ⅲa lung adenocarcinoma spreading through air spaces
10.13929/j.issn.1003-3289.2024.05.022
- VernacularTitle:18F-FDG PET/CT半定量参数预测临床Ⅰa～Ⅲa期肺腺癌经气腔播散
- Author:
Zhenzhen WANG
1
;
Xiaotian LI
;
Xingyu MU
;
Yulong ZENG
;
Weixia CHONG
;
Jie QIN
;
Zuguo LI
;
Xueqin ZHAO
;
Yang WU
;
Cuiping XU
;
Wei FU
Author Information
1. 桂林医学院附属医院核医学科,广西桂林 541000
- Keywords:
lung neoplasms;
adenocarcinoma;
neoplasm metastasis;
positron-emission tomography;
tomography,X-ray computed;
fluorodeoxyglucose F18
- From:
Chinese Journal of Medical Imaging Technology
2024;40(5):735-739
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of 18F-FDG PET/CT semi-quantitative parameters for predicting spread through air spaces(STAS)of clinical stage Ⅰa—Ⅲa lung adenocarcinoma.Methods Data of 85 patients with clinical stage Ⅰa—Ⅲ a lung adenocarcinoma who underwent preoperative 18F-FDG PET/CT were retrospectively analyzed.The patients were divided into positive group(n=23)or negative group(n=62)according to whether pathology showed STAS or not.Clinical and PET/CT data were compared between groups,and logistic analysis was performed to explore the efficacy of each parameter for predicting STAS.Results Significant differences of gender,carcinoma embryonic antigen,clinical stage,pathological grade,micropapillary growth and proportion were found between groups(all P＜0.05).The maximum,the mean,the peak standard uptake value(SUVmax,SUVmean,SUVpeak),as well as the maximum,the mean and the peak standard uptake value normalized by lean body mass(SULmax,SULmean,SULpeak),also the total lesion glycolysis(TLG)in positive group were all significantly higher than those in negative group(all P＜0.05).Patients'gender,proportion of micropapillary growth,SUVmax and SULmax were all independent risk factors of STAS of clinical stage Ⅰa—Ⅲa lung adenocarcinoma.The area under the curve(AUC)of the above parameters for predicting STAS was 0.666,0.912,0.839 and 0.842,respectively,and of the combination was 0.957.Conclusion 18 F-FDG PET/CT semi-quantitative parameters SUVmax and SULmax were helpful for predicting STAS of clinical stage Ⅰa—Ⅲ a lung adenocarcinoma,and further combination of gender and proportion of micropapillary growth could improve diagnostic efficacy.
