Resting-state functional MRI observation on relationship between functional connectivity of frontoparietal network and cognitive function in patients with cerebral small vessel disease
10.13929/j.issn.1003-3289.2024.05.018
- VernacularTitle:静息态功能MRI观察脑小血管病患者额顶网络功能连接与认知功能的关系
- Author:
Ting LEI
1
;
Wei YAN
;
Siwei TANG
;
Huiling ZHOU
;
Haiqing LI
;
Yuxing JIANG
;
Xi HE
;
Miao HE
;
Jiarui SONG
;
Lijing ZHOU
;
Yajun LI
;
Li CHEN
Author Information
1. 川北医学院附属医院放射科,四川南充 637000
- Keywords:
cerebrovascular disorders;
cognition;
magnetic resonance imaging;
functional connectivity
- From:
Chinese Journal of Medical Imaging Technology
2024;40(5):718-723
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the relationship between functional connectivity(FC)of frontoparietal network(FPN)and cognitive function in patients with cerebral small vessel disease(CSVD)using resting-state functional MRI(rs-fMRI).Methods rs-fMRI of 50 CSVD patients with cognitive impairment(CI group),65 CSVD patients with normal cognition(NC group)and 60 healthy controls(HC group),as well as outcomes of neuropsychological tests were retrospectively analyzed.Brain regions with different FC of FPN were compared among 3 groups and between each 2 groups.Partial correlation analysis was used to evaluate the correlations of FC of brain regions value being statistically different between CI and NC groups and cognitive scores.Results Significant differences of FC in bilateral cingulate gyrus,left middle frontal gyrus,right supramarginal gyrus,right inferior parietal lobule and right medial superior frontal gyrus were found among groups(FWE correction,all P＜0.05).Compared with NC group,FC of left cingulate gyrus decreased,of right inferior frontal gyrus and right medial superior frontal gyrus increased in CI group(FWE correction,all P＜0.05).The decreased FC value of left cingulate gyrus was negatively correlated with clock drawing test score in CSVD patients(r=-0.159,P=0.049).Conclusion CSVD patients with or without CI had extensive abnormal FC of FPN,and the left cingulate gyrus was associated with patient's cognitive function.
