Optimization for parameters of 5.0T pseudo continuous arterial spin labeling MRI of whole brain
10.13929/j.issn.1003-3289.2024.05.002
- VernacularTitle:5.0T全脑准连续动脉自旋标记MRI参数优化
- Author:
Dongxue LI
1
;
Xiaoyuan FAN
;
Hualu HAN
;
Shuo CHEN
;
Wei SUN
;
Hui YOU
;
Mingli LI
;
Feng FENG
Author Information
1. 中国医学科学院北京协和医学院北京协和医院协和转化医学中心放射科,北京 100730
- Keywords:
brain;
arterial spin labeling;
magnetic resonance imaging;
image quality;
prospective studies
- From:
Chinese Journal of Medical Imaging Technology
2024;40(5):643-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the optimization for parameters of 5.0T pseudo continuous arterial spin labeling(pCASL)MRI of whole brain.Methods Nine healthy adults were prospectively enrolled,and single-delay pCASL scanning was performed based on a 5.0T MR scanner with 3 sets of labeling gradients:Group A,average gradient(Gavg)=1 mT/m and the ratio of maximum gradient(Gmax)to Gavg(Gratio)=10,group B,Gavg=0.6 mT/m and Gratio=10,group C,Gavg=0.3 mT/m and Gratio=9.The labeling efficiency and cerebral blood flow(CBF)of 3 groups were compared to screen the best labeling gradient group.Results When the marked average blood flow velocity was 40 cm/s,the gradient field tolerance of group C was better than that of group A and B at the situation of reduced B1+and larger B0 offset frequency range.Under the gradient field of group C,the level of labeled artery B1 ranged from 54.19％to 75.36％,with an average of 64.71％.The labeling efficiencies of group C were all ≥85％,and all ≥90％at the average B1 level(64.71％).In the whole gray matter and almost all brain regions,CBF on pCASL under gradient field of group C was significantly higher than that of group A and B(all P＜0.05).Conclusion Low Gavg and low Gmax were the optimal parameters for 5.0T whole brain pCASL MRI.
