Fibrin Glue Reduces the Duration of Lymphatic Drainage after Lumpectomy and Level II or III Axillary Lymph Node Dissection for Breast Cancer: A Prospective Randomized Trial.
10.3346/jkms.2009.24.1.92
- Author:
Eunyoung KO
1
;
Wonshik HAN
;
Jihyoung CHO
;
Jong Won LEE
;
So Young KANG
;
So Youn JUNG
;
Eun Kyu KIM
;
Ki Tae HWANG
;
Dong Young NOH
Author Information
1. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. dynoh@plaza.snu.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Fibrin Tissue Adhesive;
Axillary Lymph Node Excision;
Lymphatic Drainage;
Breast Neoplasms
- MeSH:
Adult;
Axilla;
Breast Neoplasms/pathology/*surgery;
Drainage;
Female;
Fibrin Tissue Adhesive/*therapeutic use;
Humans;
*Lymph Node Excision;
*Mastectomy, Segmental;
Middle Aged;
Prospective Studies;
Seroma/epidemiology/etiology;
Severity of Illness Index;
Time Factors;
Tissue Adhesives/*therapeutic use
- From:Journal of Korean Medical Science
2009;24(1):92-96
- CountryRepublic of Korea
- Language:English
-
Abstract:
This randomized prospective study investigated the effect of fibrin glue use on drainage duration and overall drain output after lumpectomy and axillary dissection in breast cancer patients. A total of 100 patients undergoing breast lumpectomy and axillary dissection were randomized to a fibrin glue group (N=50; glue sprayed onto the axillary dissection site) or a control group (N=50). Outcome measures were drainage duration, overall drain output, and incidence of seroma. Overall, the fibrin glue and control groups were similar in terms of drainage duration, overall drain output, and incidence of seroma. However, subgroup analysis showed that fibrin glue use resulted in a shorter drainage duration (3.5 vs. 4.7 days; p=0.0006) and overall drain output (196 vs. 278 mL; p=0.0255) in patients undergoing level II or III axillary dissection. Fibrin glue use reduced drainage duration and overall drain output in breast cancer patients undergoing a lumpectomy and level II or III axillary dissection.
