Simulation study of proton radiography based on pixel sensors
10.3969/j.issn.1005-202X.2024.09.002
- VernacularTitle:基于像素化芯片的质子透射成像模拟研究
- Author:
Minghui LI
1
;
Yilun CHEN
;
Hu RAN
;
Jianrong DAI
;
Kuo MEN
;
Chengxin ZHAO
;
Chuanmeng NIU
;
Hongkai WANG
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科,北京 100021
- Keywords:
proton radiography;
Monte Carlo;
pixel detector;
scattering suppression
- From:
Chinese Journal of Medical Physics
2024;41(9):1064-1069
- CountryChina
- Language:Chinese
-
Abstract:
Using high-energy proton to image the region of interest can directly obtain the accurate estimation of the proton stopping power of the lesions,which is of great significance to reduce the range uncertainty in proton therapy.As a fundamental function of proton computed tomography(CT),radiographic imaging plays a crucial role in assisting clinical positioning.The study develops a compact proton CT detector based on an active array pixel CMOS chip in Monte-Carlo simulation toolkit Geant4,and evaluates the radiographic imaging capability of the system using 180 MeV protons.The angles of tracks are successfully reconstructed.CTP404,CTP528,and the CTP515 of specific materials are used for simulation,obtaining the spatial and density resolutions,and measuring the proton relative stopping power(RSP).The image signal-to-noise ratio is improved when using 2° proton scattering angle cut-off value.The spatial resolution is 3-4 lp/cm measured using CTP528 module.The density resolution is better than 0.05 g/cm3,and the RSP resolution is within 5%when CTP404 module is used.Through the imaging of CTP515 phantom of specific material,it is demonstrated that the system has potential for imaging common human tissues.
