Assessment of outcome in hypothermia therapy for neonatal hypoxic-ischemic encephalopathy using amplitude-integrated electroencephalography
10.3969/j.issn.1005-202X.2024.08.018
- VernacularTitle:基于振幅整合脑电图评价亚低温治疗新生儿缺氧缺血性脑病
- Author:
Jun HUANG
1
;
Xuetao XU
;
Liming ZENG
;
Caiyun YANG
Author Information
1. 安徽医科大学附属巢湖医院,安徽合肥 238100
- Keywords:
neonatal hypoxic-ischemic encephalopathy;
hypothermia therapy;
amplitude-integrated electroencephalography;
neuron-specific enolase
- From:
Chinese Journal of Medical Physics
2024;41(8):1036-1040
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of hypothermia therapy in neonates with hypoxic-ischemic encephalopathy(HIE)through the analysis of amplitude-integrated electroencephalography.Methods A retrospective analysis was conducted on 59 neonates with moderate to severe HIE.They were divided into observation group(n=31,hypothermia therapy)and control group(n=28,conventional therapy)according to different treatment protocols.Chi-square test,independent sample t-test,and one-factor Mann-Whitney U test were used for intergroup difference analysis.Results Significant differences between two groups were observed in lower boundary amplitude after 24 h of treatment,sleep-awake cycle after 72 h of treatment,and total scores after 72 h of treatment(P<0.05).After 48 and 72 h of treatment,the neonates in hypothermia therapy group had obviously lower neuro-specific enolase level than those in control group(P<0.05).Conclusion Early application of hypothermia therapy can significantly improve cerebral function in neonates with HIE and lower the neuro-specific enolase level.
