Efficacy evaluation of hepatic arterial infusion chemotherapy for liver cancer through quantitative analysis of digital subtraction angiography and dynamic contrast-enhanced CT
10.3969/j.issn.1005-202X.2024.07.011
- VernacularTitle:DSA联合动态增强CT定量分析肝癌HAIC的疗效
- Author:
Ruihui GAO
1
,
2
;
Yong CHEN
;
Qingle ZENG
;
Huajin PANG
;
Jian LIN
;
Jinhua HAO
Author Information
1. 中山火炬开发区人民医院放射医学中心,广东中山 528437
2. 南方医科大学南方医院血管与介入科,广东广州 510515
- Keywords:
hepatic artery infusion chemotherapy;
primary liver cancer;
efficacy analysis;
digital subtraction angiography;
dynamic contrast-enhanced CT
- From:
Chinese Journal of Medical Physics
2024;41(7):858-863
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of the quantitative analysis of digital subtraction angiography(DSA)and dynamic contrast-enhanced CT in evaluating the efficacy of hepatic artery infusion chemotherapy(HAIC)for liver cancer.Methods Fifty patients who were clinically diagnosed with primary liver cancer and treated with HAIC at least 3 times were enrolled in the study.Based on the enhanced CT scans taken within 1 week before the 1st and 3rd HAIC,patients were divided into good response group(CR+PR)and poor response group(SD+PD)according to the modified response evaluation criteria in solid tumor.The hemodynamic parameters[time to peak(TP),peak density(PV),and slope of the rising edge of the time-density curve(SU)]of liver cancer on DSA before treatment and after two HAIC,as well as the changes in the CT values of liver cancer in each phase of CT enhancement were compared,and then sensitivity analysis was conducted.Significant indicators were further analyzed with Logistic regression and ROC curve to assess their efficacies in evaluating HAIC response in liver cancer.Results The differences in pre-treatment CT values and DSA indicators between two groups were trivial(P>0.05).All patients successfully completed HAIC twice.The enhanced CT taken 1 week before the 3rd HAIC showed reductions in the arterial-and venous-phase CT values in good response group(P<0.05),while no significant difference was found in the delayed-phase CT value(P>0.05).At the 3rd HAIC,DSA angiography demonstrated significant reductions in PV and SU,and a significant prolongation of TP in good response group(P<0.05);while there were no significant differences in various indicators in poor response group.Regression analysis showed that arterial-phase CT values and DSA angiography SU were significantly correlated with therapeutic efficacy.ROC curve results indicated that arterial-phase CT values and SU were effective indicators for evaluating therapeutic efficacy.Conclusion The SU from DSA angiography and the CT values from dynamic contrast-enhanced CT which can objectively reflect the changes in blood supply of liver cancer after HAIC and are associated with HAIC efficacy can serve as radiological evidence for evaluating HAIC response.
