Analysis of resting-state functional brain network in schizophrenia patients based on graph theory
10.3969/j.issn.1005-202X.2024.07.006
- VernacularTitle:基于图论的精神分裂症患者静息态功能脑网络分析
- Author:
Xiufang REN
1
;
Jie LUO
Author Information
1. 南京农业大学理学院数学系,江苏南京 210095
- Keywords:
schizophrenia;
resting-state functional magnetic resonance imaging;
brain network;
graph theory
- From:
Chinese Journal of Medical Physics
2024;41(7):821-827
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the brain network and its topological properties in schizophrenia patients using resting-state functional magnetic resonance imaging(rs-fMRI).Methods Thirty-five schizophrenia patients(patient group)and 35 healthy subjects(control group)from the Center of Biomedical Research Excellence were collected,and the regional homogeneities of the two groups were calculated for statistical analysis.Dosenbach's 160 atlas was used to examine the whole brain functional network,and extract two sub networks of the whole brain network(default mode network and somatic motor network)for constructing a new network.The topological properties of the whole brain network and the new network were calculated.Results In schizophrenia patients,the functional connectivity between default mode network and somatic motor network and that within the default mode networks were significantly weakened(P<0.05,FDR corrected);the clustering coefficient of the whole brain network was decreased;and the global and local efficiencies of the network composed of default mode network and somatic motor network were reduced(P<0.05).Conclusion Abnormal functional connectivity is found between default mode network and somatic motor network and within default mode network in schizophrenia patients,and the significant changes of topological properties between default mode network and somatic motor network may be the key factor.In addition,this conclusion can be applied to qualitative analysis of the brain neuron stochastic differential equations corresponding to default mode network and somatic motor network,which is helpful for the physical therapy for schizophrenia.
