Generating synthetic CT in megavoltage CT image-guided adaptive radiotherapy
10.3969/j.issn.1005-202X.2024.07.005
- VernacularTitle:兆伏级CT图像引导自适应放疗中生成合成CT研究
- Author:
Yuting CHEN
1
,
2
;
Feiyu ZHOU
;
Fuli ZHANG
;
Huayong JIANG
;
Diandian CHEN
;
Yanxiang GAO
;
Yanjun YU
;
Xiaoyun LE
;
Na LU
Author Information
1. 北京航空航天大学物理学院,北京 100191
2. 解放军总医院肿瘤学部第七医学中心放疗科,北京 100700
- Keywords:
cyclic generative adversarial network;
megavoltage computed tomography;
synthetic computed tomography;
image-guided radiotherapy;
image quality
- From:
Chinese Journal of Medical Physics
2024;41(7):813-820
- CountryChina
- Language:Chinese
-
Abstract:
Objective To propose a deep learning neural network approach for transforming megavoltage computed tomography(MVCT)images of cervical cancer into pseudo kilovoltage computed tomography(kVCT)images with high signal-to-noise ratio and contrast-to-noise ratio,thus providing three-dimensional anatomical images and localization information required for adaptive radiotherapy of cervical cancer,and guiding the accelerator to achieve precise treatment.Methods The MVCT and kVCT images of 54 patients treated with cervical cancer radiotherapy were collected,with 44 cases randomly selected as the training set,and the remaining 10 cases as the test set.A cyclic generative adversarial network with gating mechanism and multi-channel data input was used to synthesize pseudo-kVCT images from MVCT images.The network training results were evaluated with imaging quality evaluation parameters,such as mean absolute error(MAE),peak signal-to-noise ratio(PSNR),and structural similarity index(SSIM).Results The MAE,PSNR,and SSIM of MVCT imagesvspseudo-kVCT(5:5)images were(24.9±0.7)HUvs(17.8±0.3)HU,(29.8±0.2)dBvs(30.7±0.2)dB,and 0.841±0.007 vs 0.898±0.003,respectively.Conclusion The generated pseudo-kVCT images have advantages in noise reduction and contrast enhancement,and can reduce the need for additional MV-kVCT electron density calibration in dose calculations.The dose calculation ability of pseudo-kVCT is comparable to that of MVCT,providing a possibility for the application of pseudo-kVCT images in image-guided adaptive radiotherapy.
