Ferroptosis:Mechanisms and Application in Tumor Treatment
10.3881/j.issn.1000-503X.15881
- VernacularTitle:铁死亡相关机制及其在肿瘤治疗中的应用
- Author:
Shihan SHAO
1
;
Shuting QIU
;
Yu LI
;
Yingying ZHANG
;
Yuejia CAO
;
Chunhong DI
;
Xiaohua TAN
Author Information
1. 杭州师范大学公共卫生学院,杭州 311121
- Keywords:
ferroptosis;
tumor cells;
mechanism;
application
- From:
Acta Academiae Medicinae Sinicae
2024;46(5):732-739
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a form of regulated cell death that depends on iron and reactive oxygen spe-cies.Different from apoptosis,necrosis,and autophagy,ferroptosis is characterized by the accumulation of lipid peroxides in cells.Studies have discovered that ferroptosis is closely associated with the occurrence and develop-ment of tumors and inducing ferroptosis in tumor cells can enhance the therapeutic effects of drugs on tumors.This article summarizes the latest research progress in ferroptosis regarding its mechanisms and associations with tumors,aiming to provide a reference for further understanding the interaction mechanisms between ferroptosis and tumors and offering new insights and targets for the treatment of tumors.
