Research Progress of Ferroptosis in Ulcerative Colitis
10.3881/j.issn.1000-503X.15918
- VernacularTitle:铁死亡在溃疡性结肠炎中的研究进展
- Author:
Qin CHEN
1
;
Lifan PENG
;
Rui XU
;
Long LOU
;
Ziyun PENG
Author Information
1. 昆明市中医医院肛肠科,昆明 650011
- Keywords:
ulcerative colitis;
ferroptosis;
disturbance of iron metabolism;
lipid peroxidation;
depletion of glutathione
- From:
Acta Academiae Medicinae Sinicae
2024;46(4):619-624
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis(UC)is a chronic inflammatory bowel disease characterized by continuous inflammation and ulcer formation in the intestinal mucosa.Its pathogenesis involves immune dysfunction,dysbio-sis of gut microbiota,and mucosal damage caused by inflammation.Ferroptosis is an iron-dependent form of cell death regulated by disturbances in iron metabolism,lipid peroxidation,and depletion of glutathione(GSH).Studies have indicated that ferroptosis plays a crucial role in the pathogenesis of UC,particularly in regulating in-flammatory responses and damaging intestinal epithelial cells.This article reviews the regulatory mechanisms and roles of ferroptosis in UC and discusses the potential therapeutic strategies to alleviate UC symptoms by modulating iron metabolism,reducing lipid peroxidation,and maintaining GSH levels,providing new targets and directions for the diagnosis and treatment of UC.
