Research Progress in Complement Receptor of the Immunoglobulin Superfamily in Regulating Liver Immunity
10.3881/j.issn.1000-503X.15803
- VernacularTitle:补体受体免疫球蛋白超家族分子在调节肝脏免疫反应中的研究进展
- Author:
Shusen YANG
1
;
Jingtao LI
;
Shuguang YAN
;
Junzhe JIAO
Author Information
1. 陕西中医药大学基础医学院,陕西咸阳 712046
- Keywords:
complement receptor of the immunoglobulin superfamily;
Kupffer cells;
liver immunity;
pathogen
- From:
Acta Academiae Medicinae Sinicae
2024;46(4):603-609
- CountryChina
- Language:Chinese
-
Abstract:
Kupffer cells(KC),an important subset of immune cells in the liver,are essential for maintaining tissue homeostasis and responding quickly to liver damage.The complement receptor of the immuno-globulin superfamily(CRIg)is a receptor protein on the KC membrane.CRIg can not only capture pathogens in the blood flowing through the liver by complement binding but also mediate immune responses by regulating im-mune cells in the liver.Recent studies have confirmed the role of CRIg in regulating liver immunity.This article reviews the main modes of action of CRIg and the research progress of CRIg in regulating liver immunity.
