Calcium Dyshomeostasis and Alzheimer's Disease
10.3881/j.issn.1000-503X.15789
- VernacularTitle:钙稳态失衡与阿尔茨海默病
- Author:
Shuang QI
1
;
Yuan YUAN
;
Wen YANG
;
Jingyang SU
;
Liying HAO
Author Information
1. 中国医科大学药学院药物毒理学教研室,沈阳 110122
- Keywords:
Alzheimer's disease;
Ca2+;
amyloid β;
tau;
signaling pathway
- From:
Acta Academiae Medicinae Sinicae
2024;46(4):592-602
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is a common neurodegenerative disease with the main manifesta-tions of progressive cognitive dysfunction,behavioral disorders,and gradual decline of living ability.The etiology of AD is complex,and the pathogenesis of this disease remains controversial.Calcium signaling plays an impor-tant role in regulating neuronal activities,including neurotransmitter release,synaptic plasticity,memory stor-age,and neuronal apoptosis.Increasing studies have shown that neuronal calcium dyshomeostasis is a major path-ological factor in the occurrence and development of AD.This article reviews the role and research progress in in-tracellular calcium dyshomeostasis in AD,including the relationship between calcium homeostasis and amyloidβ,the role of calcium/calmodulin-dependent protein kinases in tau phosphorylation,calcium signaling path-ways,the relationship between calcium homeostasis and mitochondrial function,autophagy,and neuroinflamma-tion.
