Lysine Succinylation:A New Perspective in the Treatment of Cardiovascular Diseases
10.3881/j.issn.1000-503X.15944
- VernacularTitle:赖氨酸琥珀酰化:心血管疾病治疗的新视角
- Author:
Yang MENG
1
;
Yuyang MA
;
Mingcong CHEN
;
Yang ZHANG
;
Mingyi ZHAO
Author Information
1. 中南大学湘雅三医院儿科,长沙 410013
- Keywords:
protein succinylation;
cardiovascular disease;
post-translational modification;
epigenetics
- From:
Acta Academiae Medicinae Sinicae
2024;46(3):435-443
- CountryChina
- Language:Chinese
-
Abstract:
With the continuous development of identification technologies such as mass spectrometry,omics,and antibody technology,post-translational modification(PTM)has demonstrated increasing potential in medical research.PTM as a novel chemical modification method provides new perspectives for the research on dis-eases.Succinylation as a novel modification has aroused the interest of more and more researchers.The available studies about succinylation mainly focus on a desuccinylase named sirtuin 5.This enzyme plays a key role in mod-ification and has been preliminarily explored in cardiovascular studies.This paper summarizes the influencing fac-tors and regulatory roles of succinylation and the links between succinylation and other PTMs and reviews the re-search progress of PTMs in the cardiovascular field,aiming to deepen the understanding about the role of this modification and give new insights to the research in this field.
