Research Progress of Helicobacter pylori-Associated Extragastric Diseases
10.3881/j.issn.1000-503X.15698
- VernacularTitle:幽门螺杆菌相关胃外疾病研究进展
- Author:
Jinyang LIU
1
,
2
;
Zhenghong CHEN
;
Muxi MA
;
Yongshuai LIN
;
Weiwei TAN
Author Information
1. 贵州医科大学临床医学院 贵阳 550001
2. 贵州医科大学附属医院泌尿外科贵阳 550001
- Keywords:
Helicobacter pylori;
extragastric diseases;
cross-immune reaction;
coronavirus disease 2019
- From:
Acta Academiae Medicinae Sinicae
2024;46(3):414-424
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori(Hp)is a common Gram-negative bacillus causing gastrointestinal infec-tions.It mainly exists on the surface of gastric epithelial cells and in mucus and is associated with gastric ulcers,gastric cancer,and gastric mucosa-associated lymphomas.Studies have shown that Hp can induce or exacerbate certain extragastric diseases and is associated with the occurrence of coronavirus disease 2019.It is hypothesized that Hp may be indirectly or directly involved in the occurrence and development of diseases by stimulating the production of inflammatory cytokines or inducing cross-immune reactions.In addition,Hp can enter Candida to release toxins continuously and play a role in escaping the recognition of the host immune system and the bacteri-cidal effect of drugs.This article reviews the research progress in Hp-associated extragastric diseases in recent years,aiming to draw the attention of clinical workers to Hp-associated extragastric diseases and enrich the knowledge about Hp infection for formulating countermeasures to avoid the aggravation or triggering of other disea-ses by Hp.
