Advances in Nanotechnology-Based Drug Delivery Systems in the Treatment of Hepatocellular Carcinoma
10.3881/j.issn.1000-503X.15669
- VernacularTitle:基于纳米技术的药物递送系统在肝细胞癌治疗中的研究进展
- Author:
Senlin YANG
1
;
Yang XIANG
;
Yijun YANG
Author Information
1. 中南大学湘雅医学院附属海口医院肝胆外科,海口 570208
- Keywords:
hepatocellular carcinoma;
nanotechnology;
drug/gene-delivery system;
targeted therapy
- From:
Acta Academiae Medicinae Sinicae
2024;46(3):384-392
- CountryChina
- Language:Chinese
-
Abstract:
Primary liver cancer is one of the most common malignant tumors of the digestive system,of which hepatocellular carcinoma(HCC)accounts for more than 90％of the total cases.The patients with early HCC treated by surgical resection generally demonstrate good prognosis.However,due to the insidious onset,HCC in the vast majority of patients has progressed to the mid-to-late stage when being diagnosed.As a result,surgical treatment has unsatisfactory effects,and non-surgical treatment methods generally have severe side effects and low tumor selectivity.Nanoparticles(NP)with small sizes,large specific surface areas,and unique physical and chemical properties have become potential carriers for the delivery of therapeutic agents such as drugs,genes,and cytokines.The nano-delivery systems with NP as the carrier can regulate the metabolism and transformation of drugs,genes,and cytokines in vivo from time,space,and dose via functional modification,showing great potential in the treatment of HCC.This paper introduces the current status and advantages of several common nano-delivery systems,including organic nano-carriers,inorganic nano-carriers,and exosomes,in the treatment of HCC.Furthermore,this paper summarizes the mechanisms of NP-based nano-carriers in treating HCC and provides reference for the development of new nano-delivery systems.
