Relationship Between Cerebrovascular Reactivity and Depression in Patients With End-Stage Renal Disease
10.3881/j.issn.1000-503X.15891
- VernacularTitle:终末期肾病患者脑血管反应性与抑郁状态的关系
- Author:
Shuying LI
1
;
Rui CHEN
;
Weiting TANG
;
Xiaojie MA
;
Huabin CAI
;
Yong YOU
Author Information
1. 海南医学院第二附属医院神经内科,海口 570100
- Keywords:
end-stage renal disease;
cerebrovascular reactivity;
depression;
anxiety;
transcranial Doppler sonography
- From:
Acta Academiae Medicinae Sinicae
2024;46(3):348-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between cerebrovascular reactivity(CVR)and emotional disorders in the patients undergoing continuous hemodialysis for end-stage renal disease(ESRD).Methods The clinical data of the ESRD patients undergoing continuous hemodialysis were collected.Anxiety and depression of the patients were assessed by the Hamilton anxiety scale(HAMA)and Beck depression inven-tory,respectively.The cerebral hemodynamic changes during the breath holding test were monitored by transcrani-al Doppler sonography,and the breath-holding index(BHI)was calculated.The BHI≥0.69 and BHI＜0.69 indi-cate normal CVR and abnormal CVR,respectively.Binary Logistic regression was employed to analyze the factors affecting the depressive state of ESRD patients.Results The group with abnormal CVR exhibited higher total cholesterol level(P=0.010),low density lipoprotein level(P=0.006),and incidence of depression(P=0.012)than the group with normal CVR.Compared with the non-depression group,the depression group dis-played prolonged disease course(P=0.039),reduced body mass index(P=0.048),elevated HAMA score(P=0.001),increased incidence of anxiety(P＜0.001),decreased BHI(P=0.015),and increased incidence of abnormal CVR(P=0.012).Binary Logistic regression analysis indicated anxiety as a contributing factor(OR=22.915,95％CI=2.653-197.956,P=0.004)and abnormal CVR as a risk factor(OR=0.074,95％CI=0.008-0.730,P=0.026)for depression.Conclusion Impaired CVR could pose a risk for depression in the patients with ESRD.
