Value of SOX1 and PAX1 Gene Methylation Detection in Secondary Triage of High-Grade Cervical Lesions
10.3881/j.issn.1000-503X.15734
- VernacularTitle:SOX1和PAX1基因甲基化检测对宫颈高级别病变二次分流的价值
- Author:
Yanping GUO
1
;
Qing YANG
;
Shirui WANG
;
Simin LI
;
Boyang YU
;
Xiaofeng YANG
Author Information
1. 西安交通大学第一附属医院妇产科,西安 710061
- Keywords:
SOX1;
PAX1;
methylation;
cervical lesion
- From:
Acta Academiae Medicinae Sinicae
2024;46(3):329-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of SOX1 and PAX1 gene methylation detection in the sec-ondary triage of high-grade cervical lesions.Methods Exfoliated cervical cells were collected from 122 patients tested positive for human papilloma virus(HPV)and subjected to thin-prep cytologic test(TCT)and SOX1/PAX1 gene methylation tests.Results The HPV test combined with TCT showed the sensitivity of 95.24％and the specificity of 23.75％for detecting cervical intraepithelial neoplasia(CIN)grade 2 and above(CIN2+).After the addition of the SOX1/PAX1 gene methylation detection in secondary triage,the sensitivity for detecting CIN2+was 83.33％,which had no statistically significant difference from the sensitivity of TCT combined with HPV test(P=0.078).However,the specificity reached 77.50％,which was significantly higher than that of HPV test combined with TCT(P＜0.001).The SOX1/PAX1 gene methylation level in the CIN2+group was higher than those in the normal cervical tissue and the CIN1 group(P＜0.001).The cut-off values of SOX1 and PAX1 gene methylation for CIN2+detection were-11.81 and-11.98,respectively.Conclusion Adding the detection of SOX1/PAX1 gene methylation in secondary triage significantly improves the efficiency and accuracy of CIN2+detection.
