Endosomal Sorting Complex Required for Transport:The Molecular Machine for Ensuring Proper Mitosis
10.3881/j.issn.1000-503X.15609
- VernacularTitle:内体分选转运复合体:确保有丝分裂正确进行的分子机器
- Author:
Wuluyi GAO
1
;
Yu YANG
;
Pengxia ZHANG
;
Yu SHANG
Author Information
1. 佳木斯大学基础医学院微生态-免疫调节网络与相关疾病重点实验室, 黑龙江佳木斯 154007
- Keywords:
mitosis;
endosomal sorting complex required for transport;
spindle assembly checkpoint;
cancer
- From:
Acta Academiae Medicinae Sinicae
2024;46(2):287-292
- CountryChina
- Language:Chinese
-
Abstract:
Mitosis is a key step of eukaryote proliferation.Endosomal sorting complex required for trans-port,a protein complex closely associated with membrane shearing,is involved in endosome maturation,virus budding,and autophagy.The structural and functional abnormalities of the complex are associated with the occur-rence and progression of cancer and other diseases.In this paper,we summarized the roles of the endosomal sor-ting complex required for transport in different stages of mitosis and reviewed the studies about the role of the com-plex in regulating mitosis in diseases.
