Research Progress in Nucleus Pulposus Tissue Engineering in Lumbar Intervertebral Disc
10.3881/j.issn.1000-503X.15502
- VernacularTitle:腰椎间盘髓核组织工程研究进展
- Author:
Qiang LI
1
;
Fan DING
;
Xiaoliu LIU
Author Information
1. 武汉科技大学医学院, 武汉 430065
- Keywords:
lumbar intervertebral disc degeneration;
tissue engineering;
nucleus pulposus repair;
cell transplantation
- From:
Acta Academiae Medicinae Sinicae
2024;46(1):88-97
- CountryChina
- Language:Chinese
-
Abstract:
Lumbar intervertebral disc degeneration is a common pathological process in the spine,with the main clinical symptoms of low back pain,numbness of lower limbs,and defecation dysfunction.The occur-rence and development of lumbar intervertebral disc degeneration are determined by multiple factors,and the pathophysiological and cellular mechanisms remain to be fully understood.Nucleus pulposus tissue engineering is a new biotherapy that combines biological histology with material science to treat diseases including lumbar inter-vertebral disc degeneration.Clinicians should fully learn the complex relationship between nucleus pulposus tissue engineering and lumbar intervertebral disc degeneration,which will facilitate the clinical treatment of lumbar in-tervertebral disc degeneration,the rehabilitation of lumbar intervertebral disc after treatment,and the prevention of this disease in the population.
