Circular RNA-Encoded Proteins in Gastrointestinal Cancer:A Review

VernacularTitle:环状RNA编码蛋白质在胃肠肿瘤中的研究进展
Author: Jie JIANG ¹ ; Zai LUO ; Haoliang ZHANG ; Zhengjun QIU ; Chen HUANG
Author Information

1. 上海交通大学医学院附属第一人民医院胃肠外科, 上海 200080
Keywords: circular RNA; internal ribosome entry site; protein; protein bait
From: Acta Academiae Medicinae Sinicae 2024;46(1):72-81
CountryChina
Language:Chinese
Abstract: Circular RNAs(CircRNAs)are a class of non-coding RNAs with a covalently closed-loop structure,high stability,and tissue specificity,with the production mechanisms different from linear RNAs.Recent studies have discovered that some CircRNAs can encode proteins via cap-independent translation mechanisms such as internal ribosome entry site,N6-methyladenosine,and rolling loop translation.The encoded proteins regulate homologous linear proteins or downstream signaling pathways via protein bait or other mecha-nisms,thereby exerting biological functions.Studies have shown that CircRNAs play a role in various diseases,especially in tumor progression,proliferation,invasion,and metastasis and immune regulation.Therefore,by elucidating the expression and roles of proteins encoded by CircRNAs in tumorigenesis and development,this pa-per is expected to provide new tumor markers and potential targets for tumor diagnosis and treatment.