Research Advances in Sex Determining Region Y Box 18 in Tumors
10.3881/j.issn.1000-503X.2018.01.015
- VernacularTitle:性别决定区Y框蛋白18在肿瘤中的研究进展
- Author:
Huaqi YIN
1
;
Caipeng QIN
;
Xiaowei ZHANG
;
Tao XU
Author Information
1. 北京大学人民医院泌尿外科
- Keywords:
sex determining region Y box 18;
aberrant expression;
tumor progression;
signal transduction
- From:
Acta Academiae Medicinae Sinicae
2018;40(1):98-103
- CountryChina
- Language:Chinese
-
Abstract:
Sex determining region Y box (SOX) 18 is a member of the SOX family of transcription factors.SOX18 is crucial for cardiogenesis,angiogenesis,and lymphangiogenesis during embryonic development.The mutation or aberrant expression of SOX18 is involved in many diseases.Recently,the abnormal expression of SOX18 has been confirmed to be related with the development and metastasis of various tumors.This article summarizes the functional characteristics of SOX18 and its roles in tumors.
