Contribution of Wnt Signaling Pathway to Embryo Implantation
10.3881/j.issn.1000-503X.2018.01.014
- VernacularTitle:Wnt信号通路在胚胎着床中的作用
- Author:
Yedong TANG
1
;
Zhenghong ZHANG
;
Zonghao TANG
;
Zhengchao WANG
Author Information
1. 福建师范大学生命科学学院福建省发育与神经生物学重点实验室
- Keywords:
Wnt signaling pathway;
peri-implantation;
embryo implantation
- From:
Acta Academiae Medicinae Sinicae
2018;40(1):91-97
- CountryChina
- Language:Chinese
-
Abstract:
The establishment of the endometrial receptive state,the implantation of activated blastocysts,and the decidualization of the uterine stroma are essential conditions for successful implantation in mammals and play decisive roles for subsequent pregnancy outcomes.The Wnt signaling pathway is associated with a variety of key functions such as proliferation,differentiation,apoptosis,and regeneration.During the embryo implantation,the Wnt signaling pathway plays an indispensable role.Studies have shown that the abnormal expression of Wnt signaling pathway can lead to endometriosis,endometrial cancer,and other reproductive diseases that seriously affect human health and quality of life.In this article we summarize the roles of Wnt signaling pathway in the establishment of uterine receptivity,blastocyst activation,embryo implantation,and decidualization and its regulatory mechanisms.
