Statin Therapy Regulates Serum Inflammatory Factors in the Treatment of Abdominal Aortic Aneurysms
10.3881/j.issn.1000-503X.2018.01.012
- VernacularTitle:他汀类药物对腹主动脉瘤患者血清炎性因子的调节作用
- Author:
Duan LIU
1
;
Fangda LI
;
Pengzhi LIAO
;
Jing WANG
;
Jiang SHAO
;
Yu CHEN
;
Changwei LIU
;
Bao LIU
;
Wei YE
;
Yuexin CHEN
;
Xiaojun SONG
;
Rong ZENG
;
Zhili LIU
;
Yuehong ZHENG
Author Information
1. 中国医学科学院北京协和医学院北京协和医院血管外科
- Keywords:
statins;
abdominal aortic aneurysm;
tumour necrosis factor-α;
high-sensitivity C-reactive protein
- From:
Acta Academiae Medicinae Sinicae
2018;40(1):78-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of statin therapy on serum inflammatory cytokines in patients with abdominal aortic aneurysm (AAA).Methods The clinical data of 126 AAA patients who were hospitalized in the Department of Vascular Surgery,Peking Union Medical College Hospital,from September 2014 to September 2017 were retrospectively analyzed.Patients were divided into treatment group and control group according to whether statins were used or not.The levels of serum lipids and serum inflammatory factors were compared between these two groups.Results There was no significant difference in gender,age,body height,body weight,smoking ratio,and AAA diameter between these two groups (all P ＞ 0.05).While the levels of total cholesterol (TC),triglyceride (TG),low-density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were not significantly different before treatment (all P ＞ 0.05),the treatment group had significantly lower TC (t =2.868,P =0.009),TG (t =3.472,P =0.006),and LDL-C (t =3.924,P =0.005) and significantly higher HDL-C level (t =3.322,P =0.007) after treatment.In addition,the concentrations of interleukin (IL)-1β,IL-6,high-sensitivity C-reactive protein (hs-CRP),and tumor necrosis factor-α (TNF-α) were not significantly different between these two groups before treatment (all P ＞0.05);after treatment,the serum levels of IL-1β and IL-6 in the treatment group were (224.32 ± 78.54) and (116.49 ± 19.64) ng/L,respectively,which were lower than those in the control group [(254.68 ±96.77)ng/L (t=1.765,P=0.058) and (126.71 ±23.59) ng/L (t=1.692,P=0.063)],although the differences were not statistically significant.The serum levels of hs-CRP and TNF-α in the treatment group were (6.46 ± 1.24) mg/L and (0.77 ± 0.21) μg/L,respectively,which were significantly lower than those in the control group [(10.93 ± 4.18) mg/L (t =2.007,P =0.012) and (1.28 ± 0.49) μg/L (t =2.144,P =0.016)].Conclusion Statin treatment reduces the levels of hs-CRP and TNF-α in AAA patients.
