The Factors That Influence the Consistency of International Normalized Ratio of Prothrombin Time
- VernacularTitle:影响凝血酶原时间国际标准化比值一致性的因素
- Author:
Wei SU
1
;
Feng-Qin REN
Author Information
1. Clinical Laboratory PUMC Hospital CAMS and PUMC
- From:
Acta Academiae Medicinae Sinicae
2001;23(2):196-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the factors that influence the consistency of international normalized ra tio (INR) of prothrombin time. Methods Using the same automated blood coagulation analyzer and INR calibration plasma with two different types of prothrombin time (PT) reagent to assay the INR values of 19 controls (group 1), 12 patients who took long-term anticoagulant orally (group 2),12 patients who took it at the first time (group 3) and 8 patients who took long-tern anticoagulant togeth er with cephalosperin N (group 4). Results The two kinds of reagents gave quite different INR val ues in all four groups (P＜0.01). The INR difference in group 3 (0.23±0.07, n = 12) was larger than that in group 2 (0.51±0.20, n=12) (P＜0.01) .The difference in group 4 (0.61 ±0.21, n=8) was larger than that in group 2 ( P＜0.01). Conclusions The factors that may influence INR consistency are the source and sensitivity of the reagents , as well as the period of the anticoagulant been taken and the other drugs taken at the same time.
