Effects of SDF-1 α and Its Receptor on Regulation of Hematopoiesis
- VernacularTitle:基质细胞衍生因子-1及其受体在造血调控中的作用
- Author:
Jin-Xiang FU
1
;
Xue-Guang ZHANG
Author Information
1. Suzhou University
- From:
Acta Academiae Medicinae Sinicae
2001;23(2):184-188
- CountryChina
- Language:Chinese
-
Abstract:
Hematopoietic stem/progenitor cell transplantation is one of main choices for treating patients with malignant tumor or heredity diseases in recently year. The homing of hematopoietic stem cells(HSC) is a committed step to ensure the bone marrow hematopoiesis reconstitution. Recent studies have showed that stromal cell derived factor-1 (SDF-1) and its receptor has important effects on proliferation, differentiation, homing of HSC to bone marrow and hematopoiesis reconstitution. The purpose of this review is to give a recent update informations on mechanism of hematopoiesis regulation mediated by SDF-1 and its receptor
