Perinatal management and challenges of systemic autoimmune diseases
10.3760/cma.j.cn431274-20240904-01367
- VernacularTitle:系统性自身免疫性疾病的围孕期管理和挑战
- Author:
Youmei CHEN
1
;
Jianxin ZHEN
;
Chenhong WANG
;
Quanfu ZHANG
Author Information
1. 香港中文大学妇女儿童医学中心（深圳）妇产科，深圳 518133
- Keywords:
Autoimmune diseases;
Pregnancy complications;
Pregnancy outcome
- From:
Journal of Chinese Physician
2024;26(11):1601-1606
- CountryChina
- Language:Chinese
-
Abstract:
Pregnancy with autoimmune diseases is a challenging area that involves multidisciplinary management of immunology, rheumatology, and obstetrics. During pregnancy, the maternal immune system dynamically regulates the balance between maintaining immune tolerance to the fetus and autoimmune. However, for women with common systemic autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid arthritis, this balance can be upset, leading to exacerbation or recurrence of the disease and significantly increasing the risk of pregnancy complications. This paper describes the adaptive changes of the immune system during pregnancy and the effects of systemic autoimmune diseases on pregnancy outcomes, proposes multidisciplinary management strategies and challenges in perinatal pregnancy, and aims to provide references for optimizing clinical practice and improving pregnancy outcomes.
