Clinicopathologic study of ovarian granulosa cell tumors.
- Author:
In ho LEE
1
;
Yong Soon KWON
;
Ho Suap HAHN
;
Seok Geun YOON
;
Jae Shik HONG
;
Tae Jin KIM
;
Ki Heon LEE
;
Jae Uk SHIM
;
Jung Eun MOK
;
Kyung Taek LIM
Author Information
1. Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea. mbg215@godpeople.com
- Publication Type:Original Article
- Keywords:
Granulosa cell tumor;
Ovary;
Clinical study
- MeSH:
Endometrial Hyperplasia;
Endometrial Neoplasms;
Female;
Fertility;
Follow-Up Studies;
Granulosa Cell Tumor;
Granulosa Cells;
Humans;
Hysterectomy;
Medical Records;
Ovary;
Pregnancy;
Recurrence;
Retrospective Studies;
Uterine Hemorrhage
- From:Korean Journal of Obstetrics and Gynecology
2009;52(4):429-436
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study was to evaluate the clinicopathologic characteristics of granulosa cell tumor of the ovary (OGCT). METHODS: We retrospectively reviewed the medical records of 27 patients with OGCT at our hospitals from January 1995 to December 2003. RESULTS: The mean age was 48.3 years (24~70) and mean follow up period was 56.7 months (12~102). The most common symptom was vaginal bleeding (n=11, 40.7%). The tumors were ranging from 3 cm to 21 cm in diameter (mean: 9.9). Post-surgical FIGO stage was stage I in 20 (74.1%), stage II in 6 (22.2%), and stage III in 1 (3.7%). Endoemetrial samples were available in 21 patients and the results were endometrial carcinoma in 1 and endometrial hyperplasias in 5. Staging operation was performed in 17, unilateral salpingo-oophorectomy in 6, total hysterectomy and bilateral salpingo-oophorectomy in 2, and fertility sparing operation in 2. Postoperative chemotherapy was administered in 13 patients (48.2%). Two patients had recurred and recurrence rate was 7.4% (2/27). Two recurred patients finally died of the disease at 42 months and 103 months after first operation respectively. During follow-up period, 2 patients had 3 pregnancies and all of them delivered at term. CONCLUSION: These results shows that most OGCT is detected in early stage and have relatively excellent survival. However, because OGCT is a slow-growing tumor and has a late recurrence, long time follow-up is required.
