Effect of prior statins use on the mortality rate among adult sepsis patients with type 2 diabetes
10.3760/cma.j.cn431274-20230928-00334
- VernacularTitle:既往使用他汀类药物对合并2型糖尿病的脓毒症成年患者病死率的影响
- Author:
Qiuhua ZHANG
1
;
Zhiming ZHANG
;
Jianye DU
;
Tong LIN
;
Chang JIAO
;
Jianmin LI
;
Jing ZHOU
Author Information
1. 唐山南湖医院心内二科，唐山 063000
- Keywords:
Diabetes mellitus, type 2;
Sepsis;
Statins;
Mortality
- From:
Journal of Chinese Physician
2024;26(9):1356-1359
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of prior statins use on the in-hospital mortality of adult sepsis patients with type 2 diabetes (T2DM).Methods:A total of 3 545 sepsis patients with T2DM were retrospectively collected from the Critical Care Medical Information Market (MIMIC Ⅳ) database, with in-hospital mortality rate as the outcome variable. According to whether they have taken statins in the past, they were divided into two groups and propensity score matching was used. Multivariate Cox regression analysis was performed to calculate the adjusted hazard ratio ( HR) and 95% CI, and the relationship between past statins use and in-hospital mortality in sepsis patients with T2DM was analyzed. Results:A total of 3 545 sepsis patients with T2DM were included between 2008 and 2016. 1 556 patients used statins before admission, and 1 989 patients did not use statins. After propensity score matching, the number of patients who had previously used statins and those who had not used statins were 1 230 and 1 298, respectively. After adjusting for potential confounding factors, it was found that previous use of statins was associated with a reduced in-hospital mortality rate ( HR=0.82, 95% CI: 0.61-0.99, P=0.038). Kaplan Meier curves showed that sepsis patients with T2DM who used statins before admission had a lower in-hospital mortality rate (Log rank test: P<0.001). Conclusions:Pre admission use of statins may be associated with a reduced mortality rate in sepsis patients with concomitant T2DM.
