Correlation analysis between T lymphocyte, TGF-β levels and disease activity in patients with lupus nephritis
10.3760/cma.j.cn431274-20240105-00041
- VernacularTitle:狼疮肾炎患者T淋巴细胞、TGF-β水平与疾病活动度的相关性分析
- Author:
Bangjuan SHANG
1
;
Juan WANG
;
Min TIAN
;
Cheng LI
Author Information
1. 咸阳市中心医院肾病内科，咸阳 712000
- Keywords:
Lupus nephritis;
T lymphocytes;
Transforming growth factor-β;
Disease activity;
Prognosis
- From:
Journal of Chinese Physician
2024;26(9):1338-1342
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between T lymphocyte and transforming growth factor beta (TGF-β) levels and disease activity in patients with lupus nephritis (LN).Methods:A retrospective analysis was conducted on the clinical data of 160 patients with systemic lupus erythematosus (SLE) treated at the Xianyang Central Hospital from September 2018 to September 2023, including 100 LN patients and 60 non LN patients. Another 50 healthy volunteers who underwent physical examination at the Xianyang Central Hospital Physical Examination Center during the same period were selected as the control group. The levels of T lymphocytes [leukocyte differentiation antigen 3 (CD3 + ), leukocyte differentiation antigen 4 (CD4 + ), helper T cell 22 (Th22)] and TGF-β were compared among all subjects. The levels of T lymphocytes and TGF-β in LN patients with different disease activity and prognosis were compared. Spearman correlation coefficient was used to analyze the correlation between T lymphocytes, TGF-β levels and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score. Results:The serum levels of CD3 + and CD4 + in the LN group were lower than those in the non LN group, while the levels of Th22 and TGF-β were higher than those in the non LN group. The levels of CD3 + and CD4 + in the non LN group were lower than those in the control group, while the levels of Th22 and TGF-β were higher than those in the control group ( F=217.170, 311.154, 84.268, 56.952, all P<0.05); Comparison of serum CD3 + and CD4 + levels in LN patients with different disease activities: stable phase>mild activity>moderate activity>severe activity. Comparison of Th22 and TGF-β levels: stable phase
