Clinical efficacy of ultrasound-guided paravertebral nerve block combined with platelet rich plasma injection for postherpetic neuralgia
10.3760/cma.j.cn431274-20240818-01274
- VernacularTitle:超声引导下椎旁神经阻滞联合富血小板血浆注射对带状疱疹后遗神经痛的临床疗效
- Author:
Ruirui ZHU
1
;
Xuewu LIN
Author Information
1. 蚌埠医科大学第一附属医院麻醉科，蚌埠 233004
- Keywords:
Neuralgia, postherpetic;
Nerve block;
Paraspinal nerve;
Platelet-rich plasma
- From:
Journal of Chinese Physician
2024;26(9):1299-1303
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical therapeutic effect of ultrasound-guided paravertebral nerve block combined with platelet rich plasma (PRP) injection on patients with postherpetic neuralgia (PHN).Methods:Sixty PHN patients diagnosed at the First Affiliated Hospital of Bengbu Medical University from August 2023 to June 2024 were selected and randomly divided into a control group and an observation group using a random number table. The control group received ultrasound-guided paravertebral nerve block, while the observation group received PRP injection in addition to the control group. The two groups were compared before treatment (T 0), 1 week after treatment (T 1), 2 weeks after treatment (T 2), 3 weeks after treatment (T 3), 4 weeks after treatment (T 4), and 8 weeks after treatment (T 5), pain Visual Analogue Scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Dermatology Quality of Life Index (DLQI) scores, and incidence of adverse reactions at each time point. Results:The pain VAS, PSQI, and DLQI scores of both groups of patients at T 1, T 2, T 3, T 4, and T 5 time points were reduced compared to T 0, and the pain VAS, PSQI, and DLQI scores of the observation group at T 1 to T 5 time points were lower than those of the control group (all P<0.05). The incidence of adverse reactions in the control group was 26.6%(8/30), while in the observation group it was 6.6%(2/30), with a statistically significant difference between the two groups (χ 2=4.320, P<0.05). The total effective rate of the control group [70.0%(21/30)] was lower than that of the observation group [93.3%(28/30)], with a statistically significant difference between the two groups (χ 2=5.454, P<0.05). Conclusions:The combined application of ultrasound-guided paravertebral nerve block and PRP injection for the treatment of PHN can significantly alleviate patients′ pain symptoms, improve their sleep and quality of life, with relatively few side effects and high safety.
