Research progress on pathogenic mechanism and treatment of high-risk cervical human papillomavirus infection
10.3760/cma.j.cn431274-20231023-00433
- VernacularTitle:宫颈高危型人乳头瘤病毒感染致病机制及治疗研究进展
- Author:
Ying XU
1
;
Manzhen ZUO
;
Feng HUANG
Author Information
1. 三峡大学人民医院妇产科，宜昌 443000
- Keywords:
Papillomavirus infections;
High-risk human papillomavirus
- From:
Journal of Chinese Physician
2024;26(8):1277-1280
- CountryChina
- Language:Chinese
-
Abstract:
Human papillomavirus (HPV) is a small, non enveloped circular double stranded DNA virus with special epitheliophilicity, which is one of the common sexually transmitted diseases in women. Currently, more than 200 different HPV genotypes have been discovered. Persistent high-risk HPV infection is closely related to cervical and vaginal intraepithelial neoplasia and cervical cancer, and lacks typical clinical symptoms in the early stages, seriously endangering women's health. The latest research uses HPV DNA quantification and HPV E6/E7 gene testing as diagnostic criteria and efficacy evaluation indicators for HPV infection. At present, the main methods for treating high-risk cervical HPV infections include physical therapy, drug therapy, surgical treatment, and HPV vaccine intervention. Due to the complex immune escape mechanism of HPV, traditional treatment methods have shortcomings such as long treatment cycles, high recurrence rates, multiple surgeries, and the possibility of complications such as cervical dysfunction and miscarriage. This study reviews the pathogenesis and treatment progress of high-risk cervical HPV in recent years, providing new diagnostic and therapeutic ideas for clinical practice.
