Research progress on the relationship between miR-155 and osteoporosis in type 2 diabetes patients
10.3760/cma.j.cn431274-20230717-00013
- VernacularTitle:miR-155与2型糖尿病患者骨质疏松关系的研究进展
- Author:
Sihan DUAN
1
;
Hong LIU
;
Zhangxin WEN
Author Information
1. 吉首大学医学院，吉首 416099
- Keywords:
Diabetes mellitus, type 2;
Osteoporosis;
miR-155
- From:
Journal of Chinese Physician
2024;26(8):1269-1273
- CountryChina
- Language:Chinese
-
Abstract:
Biochemical indicators of bone metabolism may change at the initial stage of type 2 diabetes, and the risk of osteoporosis and fracture in patients is significantly increased compared with normal people. Osteoporosis is a systemic bone disease characterized by low bone mass and degeneration of bone tissue microstructure, leading to increased bone fragility and susceptibility to fractures. The main mechanism of type 2 diabetes is insulin resistance (IR). A large number of clinical studies have shown that there is a relationship between insulin resistance and osteoporosis. There is a close association between miR-155 in microRNAs (miRNAs) and IR. At present, studies have found that the increased expression of miR-155 can improve insulin sensitivity, and IR is a potential mechanism leading to diabetes induced osteoporosis. However, although the risk of osteoporosis or fracture in type 2 diabetes patients increases, their bone mineral density (BMD) values are still normal or even slightly increased. Therefore, at present, the relevant mechanism of osteoporosis fracture in type 2 diabetes cannot be fully explained by BMD alone. This article mainly reviews the progress of the relationship between miR-155 and osteoporosis in type 2 diabetes patients.
