Clinical characteristics analysis of 15 cases of eosinophilic granulomatous polyangiitis
10.3760/cma.j.cn431274-20230805-00086
- VernacularTitle:嗜酸性肉芽肿性多血管炎15例临床特征分析
- Author:
Juan LIU
1
;
Lu HU
;
Yuzhou DUAN
;
Hongyang SHI
Author Information
1. 西安交通大学第二附属医院呼吸与危重症医学科，西安 710004
- Keywords:
Eosinophilic granulomatosis with polyangiitis;
Asthma;
Anti-neutrophil cytoplasmic antibodies
- From:
Journal of Chinese Physician
2024;26(5):727-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics of eosinophilic granulomatous polyangiitis (EGPA) and provide a basis for clinical diagnosis and treatment.Methods:A retrospective analysis was conducted on the epidemiology, clinical manifestations, laboratory tests, imaging and pathological characteristics, and treatment outcomes of 15 cases of eosinophilic granulomatous vasculitis.Results:Fifteen patients with eosinophilic granulomatous vasculitis were aged (50.7±17.2)years old, with a median time of 182.5 days from onset to diagnosis. Thirteen patients presented with respiratory symptoms as the initial diagnosis, while the other two presented with skin and nervous system damage. These patients were all accompanied by an increase in peripheral blood eosinophils, fluctuating between 10.6% and 60.94%. Thirteen patients had respiratory symptoms, mainly cough, sputum production, shortness of breath, and varied chest computed tomography (CT) findings. Histopathology or alveolar lavage fluid also showed changes in eosinophil count.Conclusions:The clinical manifestations of eosinophilic granulomatous vasculitis are diverse, often involving the respiratory system, as well as multiple systems such as the circulatory system, digestive system, nervous system, urinary system, and skin. However, due to its frequent early manifestations of wheezing, it is often misdiagnosed as refractory asthma. Improving the understanding of eosinophilic granulomatous vasculitis and improving the level of early diagnosis can help improve the prognosis of patients.
