Differences in clinical characteristics and prognosis analysis between children and adults with ocular toxocariasis disease
10.3760/cma.j.cn431274-20240402-00572
- VernacularTitle:儿童与成人眼弓蛔虫病临床特征差异与预后分析
- Author:
Shiqun LIN
1
;
Xingyu XIAO
;
Yan ZHOU
;
Meifen ZHANG
;
Youxin CHEN
;
Rongping DAI
Author Information
1. 中国医学科学院北京协和医院眼科 中国医学科学院北京协和医学院，北京 100730
- Keywords:
Ocular toxocariasis;
Optical coherence tomography;
Prognosis
- From:
Journal of Chinese Physician
2024;26(5):646-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the differences in clinical characteristics between children and adults with ocular roundworm disease (OT) and analyze its prognosis.Methods:This study was a retrospective cohort study, which included 37 patients (37 eyes) with ocular toxocariasis disease admitted to the Department of Ophthalmology, Peking Union Medical College Hospital from September 2017 to September 2023, including 12 adult patients (12 eyes) and 25 pediatric patients (25 eyes). We compared the clinical differences and prognosis between pediatric and adult patients.Results:16% (4/25) of the affected eyes in the child group had high intraocular pressure, while the adult group had no affected eyes with high intraocular pressure. All affected eyes showed vitreous inflammation, and there was a statistically significant difference in the level of vitreous inflammation between the two groups ( P<0.05). The majority of OT types in the adult group were atypical phenotype OT, with a statistically significant difference compared to the child group ( P<0.05). The proportion of retinal vasculitis, macular edema, and proliferative membrane on the retinal surface in the adult group was higher than that in the child group (all P<0.05). After oral treatment with albendazole and corticosteroids, the thickness of the macular fovea and anterior segment inflammation in both groups were significantly improved (all P<0.05). The proportion of local use of steroid drugs in the children′s group was higher than that in the adult group ( P<0.05). Conclusions:Compared with pediatric OT, adult OT mostly has no characteristic signs, and adult OT is mainly characterized by atypical phenotype OT. Adult OT has a better prognosis and is less prone to recurrent inflammation. In most cases, antiparasitic and anti-inflammatory treatments are safe and effective.
